Description
Aim of this project is to investigate the detailed
mechanisms through which mixtures of pesticides and other
chemicals affect terrestrial invertebrates. Comprising
researchers from CEH, University of Cardiff, University of
York and Imperial College, this project will look at
synergism – where the interaction between various chemicals
has a greater impact than the individual effects added
together. We will use a range of ecological, analytical,
genetic and modelling methods to identify cases where a
mixture of exposures results in greater effects than can be
predicted by current widely used models, the biological
causes of such effects and their impact on invertebrate
populations and communities.
My role
Collaborating with Sylvain Bart on the development
and application of toxicokinetic-toxicodynamic model (i.e.,
GUTS and DEBtox). Specifically the model extensions to deal
with mixture toxicity and the statistical apsects of
parameter estimation, uncertainty quantification, and error
propagation. I am advising on the data analysis and in the
preparation of scientific publications.
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Output: Publications (as first or co-author)
- Bart S, T Jager, A Robinson, E Lahive, D Spurgeon and
R Ashauer (2021). Predicting mixture effects over time
with toxicokinetic-toxicodynamic models (GUTS):
assumptions, experimental testing & predictive
power. Environ Sci Technol 55(4):2430-2439. https://dx.doi.org/10.1021/acs.est.0c05282
(Open Access).
- Bart S, S Short, T Jager, EJ Eagles, A Robinson, C
Badder, E Lahive, DJ Spurgeon and R Ashauer (2022). How
to analyse and account for interactions in mixture
toxicity with toxicokinetic-toxicodynamic models. Sci
Total Environ 843:157048. https://doi.org/10.1016/j.scitotenv.2022.157048
(Open Access).
- ...
Output: Presentations (as presenter and as contributor)
- Predicting mixture toxicity effects over time with
toxicokinetic-toxicodynamic models (GUTS): assumptions,
experimental testing & predictive power. Bart S, T
Jager, A Robinson, C Badder, E Lahive, H Hesketh, DJ
Spuregon and R Ashauer. Poster presentation by Sylvain
Bart at the 30th
SETAC Europe conference in virtual space, 3-7 May
2020.
- General Unified Threshold Model of Survival (GUTS) –
Extending the toxicokinetic-toxicodynamic framework for
interaction analyses (synergism and antagonism). Bart S,
T Jager, A Robinson, C Badder, E Lahive, C Svendsen, DJ
Spurgeon and R Ashauer. Platform presentation for the 31st SETAC Europe
conference in virtual space, 3-6 May 2021.
- Enchytraeus crypticus, a suitable soil species
for DEB-TKTD modelling. Bart S, T Jager, A Robinson, E
Lahive, D Spuregon and R Ashauer. Poster presentation by
Sylvain Bart at the 7th internal
symposium on DEB theory in virtual space, 17-28
May 2021.
- Mixture effects of two insecticides on the Enchytraeus
crypticus life cycle predicted with a DEB-TKTD
model. Bart S, T Jager, A Robinson, DJ Spurgeon and R
Ashauer. Poster presentation by Sylvain Bart at the 32nd SETAC Europe
Conference, Copenhagen Denmark.
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